{"query":{"product_cat":"withanolides-withanosides"},"query_vars":{"product_cat":"withanolides-withanosides","error":"","m":"","p":0,"post_parent":"","subpost":"","subpost_id":"","attachment":"","attachment_id":0,"name":"","pagename":"","page_id":0,"second":"","minute":"","hour":"","day":0,"monthnum":0,"year":0,"w":0,"category_name":"","tag":"","cat":"","tag_id":"","author":"","author_name":"","feed":"","tb":"","paged":0,"meta_key":"","meta_value":"","preview":"","s":"","sentence":"","title":"","fields":"all","menu_order":"","embed":"","category__in":[],"category__not_in":[],"category__and":[],"post__in":[],"post__not_in":[],"post_name__in":[],"tag__in":[],"tag__not_in":[],"tag__and":[],"tag_slug__in":[],"tag_slug__and":[],"post_parent__in":[],"post_parent__not_in":[],"author__in":[],"author__not_in":[],"search_columns":[],"orderby":"menu_order title","order":"ASC","meta_query":[],"tax_query":{"relation":"AND","0":{"taxonomy":"product_visibility","field":"term_taxonomy_id","terms":[36],"operator":"NOT IN"}},"wc_query":"product_query","posts_per_page":12,"ignore_sticky_posts":false,"suppress_filters":false,"cache_results":true,"update_post_term_cache":true,"update_menu_item_cache":false,"lazy_load_term_meta":true,"update_post_meta_cache":true,"post_type":"","nopaging":false,"comments_per_page":"50","no_found_rows":false,"taxonomy":"product_cat","term":"withanolides-withanosides"},"tax_query":{"queries":{"relation":"AND","0":{"taxonomy":"product_visibility","terms":[36],"field":"term_taxonomy_id","operator":"NOT IN","include_children":true},"1":{"taxonomy":"product_cat","terms":["withanolides-withanosides"],"field":"slug","operator":"IN","include_children":true}},"relation":"AND","queried_terms":{"product_cat":{"terms":["withanolides-withanosides"],"field":"slug"}},"primary_table":"wp_posts","primary_id_column":"ID"},"meta_query":{"queries":[],"relation":null,"meta_table":null,"meta_id_column":null,"primary_table":null,"primary_id_column":null},"date_query":false,"queried_object":{"term_id":797,"name":"Withanolides & Withanosides","slug":"withanolides-withanosides","term_group":0,"term_taxonomy_id":797,"taxonomy":"product_cat","description":"","parent":0,"count":7,"filter":"raw"},"queried_object_id":797,"request":"SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id)\n\t\t\t\t\t WHERE 1=1 AND ( \n wp_posts.ID NOT IN (\n\t\t\t\tSELECT object_id\n\t\t\t\tFROM wp_term_relationships\n\t\t\t\tWHERE term_taxonomy_id IN (36)\n\t\t\t) \n AND \n wp_term_relationships.term_taxonomy_id IN (797)\n) AND ((wp_posts.post_type = 'product' AND (wp_posts.post_status = 'publish')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.menu_order ASC, wp_posts.post_title ASC\n\t\t\t\t\t LIMIT 0, 12","posts":[{"ID":10676,"post_author":"4","post_date":"2026-04-10 10:56:02","post_date_gmt":"2026-04-10 14:56:02","post_content":"

12-Deoxywithastramonolide (CAS 60124-17-6) is a natural steroidal lactone from the withanolide class. It grows in the roots and leaves of Withania somnifera (L.) Dunal,<\/a> the plant commonly known as Ashwagandha or Indian ginseng.<\/p>\r\n

This adaptogenic herb has held an important place in Ayurvedic traditions for centuries. People have valued it for boosting energy levels, easing stress, and supporting overall well-being. Withanolides form the main group of active compounds that drive these traditional benefits.<\/p>\r\n

12-Deoxywithastramonolide attracts attention for its anti-inflammatory and antioxidant effects. For example, it influences cell signaling pathways.(1) It lowers inflammation markers such as TNF-\u03b1 and raises anti-inflammatory cytokines like IL-10. In addition, the compound helps protect cells from oxidative stress. This action adds to the overall protective benefits of Ashwagandha. Unlike stronger withanolides, it often shows balanced activity, which makes it valuable in herbal formulations.<\/p>\r\n

As a useful marker for quality assessment, 12-Deoxywithastramonolide plays a key role in standardizing<\/a> Ashwagandha extracts. Manufacturers use these extracts widely in nutraceuticals, dietary supplements, and traditional herbal products. Careful measurement ensures steady potency, uniform batches, and full compliance with industry standards.<\/p>\r\n

Withaferin A (CAS 5119-48-2) is a powerful steroidal lactone and one of the most abundant withanolides found in Withania somnifera<\/em> (L.) Dunal<\/a>, commonly known as Ashwagandha or Indian ginseng.<\/p>\r\n

This adaptogenic herb has played a central role in Ayurvedic medicine for centuries. People have traditionally used it to increase energy, reduce stress, and promote overall wellness. Withanolides form the core group of active compounds that deliver these classic benefits.<\/p>\r\n

Withaferin A stands out for its strong anti-inflammatory, antioxidant, and anticancer activities. For example, it targets multiple pathways in cancer cells by inducing apoptosis, inhibiting cell proliferation, and disrupting key survival signals such as NF-\u03baB and Hsp90.(1) These actions make it a valuable subject for research across various cancer types, including breast, prostate, and lung cancers. In addition, Withaferin A helps calm excessive inflammation and protects cells from oxidative damage, supporting its broad therapeutic potential.<\/p>\r\n

Unlike some other withanolides that focus more on neuroprotection or mild adaptogenic effects, Withaferin A shows more potent and direct effects on cell cycle regulation and tumor suppression. It also contributes to the overall health-promoting profile of Ashwagandha extracts.<\/p>\r\n

As an important marker compound, Withaferin A is critical for the standardization<\/a> and quality control of Ashwagandha-based products. These products are widely used in nutraceuticals, dietary supplements, and phytopharmaceutical formulations. Precise quantification helps maintain consistent potency, batch-to-batch uniformity, and compliance with regulatory requirements.<\/p>\r\n

Planta Analytica provides high-purity Withaferin A reference standards. They are ideal for HPLC, UPLC, LC-MS, and other advanced analytical techniques, as well as for pharmacological studies and natural product research.<\/p>\r\n

References:<\/strong><\/p>\r\n

(1) Evaluating anticancer properties of Withaferin A\u2014a potent phytochemical from Withania<\/a> somnifera<\/a><\/p>","post_title":"Withaferin A","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"withaferin-a","to_ping":"","pinged":"","post_modified":"2026-04-10 15:26:13","post_modified_gmt":"2026-04-10 19:26:13","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=10672","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":10650,"post_author":"4","post_date":"2026-04-09 15:24:46","post_date_gmt":"2026-04-09 19:24:46","post_content":"