Withanoside IV

Withanoside IV (CAS 362472-81-9) is a glycosylated steroidal lactone from the withanolide group. It occurs naturally in the roots and leaves of Withania somnifera (L.) Dunal, the plant commonly known as Ashwagandha or Indian ginseng.

This adaptogenic herb has held a valued place in Ayurvedic traditions for centuries. People have used it to raise energy, sharpen mental focus, and help the body manage stress. Withanolides and their glycosides form the main active compounds that support these traditional benefits.

Withanoside IV attracts scientific interest for its neuroprotective effects.(1) For example, it promotes neurite outgrowth in damaged neurons. In addition, it helps rebuild axons, dendrites, and synapses. These actions make it useful for research on memory loss and neurodegenerative conditions such as Alzheimer’s disease. Moreover, studies show that Withanoside IV converts in the body to its active metabolite sominone, which supports neuronal repair and improves memory performance in animal models.

Unlike some withanolides that focus mainly on inflammation or cell cycle control, Withanoside IV stands out for its role in synaptic reconstruction and cognitive support. It also adds to the overall protective qualities of Ashwagandha extracts by shielding nerve cells from damage.

As a key marker for quality control, Withanoside IV plays an important role in standardizing Ashwagandha extracts. These extracts appear widely in nutraceuticals, dietary supplements, and herbal health products. Accurate measurement ensures steady potency, consistent batches, and compliance with industry standards.