12-Deoxywithastramonolide

12-Deoxywithastramonolide (CAS 60124-17-6) is a natural steroidal lactone from the withanolide class. It grows in the roots and leaves of Withania somnifera (L.) Dunal, the plant commonly known as Ashwagandha or Indian ginseng.

This adaptogenic herb has held an important place in Ayurvedic traditions for centuries. People have valued it for boosting energy levels, easing stress, and supporting overall well-being. Withanolides form the main group of active compounds that drive these traditional benefits.

12-Deoxywithastramonolide attracts attention for its anti-inflammatory and antioxidant effects. For example, it influences cell signaling pathways.(1) It lowers inflammation markers such as TNF-α and raises anti-inflammatory cytokines like IL-10. In addition, the compound helps protect cells from oxidative stress. This action adds to the overall protective benefits of Ashwagandha. Unlike stronger withanolides, it often shows balanced activity, which makes it valuable in herbal formulations.

As a useful marker for quality assessment, 12-Deoxywithastramonolide plays a key role in standardizing Ashwagandha extracts. Manufacturers use these extracts widely in nutraceuticals, dietary supplements, and traditional herbal products. Careful measurement ensures steady potency, uniform batches, and full compliance with industry standards.

Planta Analytica supplies high-purity 12-Deoxywithastramonolide reference standards. They work well with HPLC, UPLC, LC-MS, and other modern analytical tools. They also support pharmacological studies and natural product development.