{"query":{"product_cat":"kavalactones"},"query_vars":{"product_cat":"kavalactones","error":"","m":"","p":0,"post_parent":"","subpost":"","subpost_id":"","attachment":"","attachment_id":0,"name":"","pagename":"","page_id":0,"second":"","minute":"","hour":"","day":0,"monthnum":0,"year":0,"w":0,"category_name":"","tag":"","cat":"","tag_id":"","author":"","author_name":"","feed":"","tb":"","paged":0,"meta_key":"","meta_value":"","preview":"","s":"","sentence":"","title":"","fields":"all","menu_order":"","embed":"","category__in":[],"category__not_in":[],"category__and":[],"post__in":[],"post__not_in":[],"post_name__in":[],"tag__in":[],"tag__not_in":[],"tag__and":[],"tag_slug__in":[],"tag_slug__and":[],"post_parent__in":[],"post_parent__not_in":[],"author__in":[],"author__not_in":[],"search_columns":[],"orderby":"menu_order title","order":"ASC","meta_query":[],"tax_query":{"relation":"AND","0":{"taxonomy":"product_visibility","field":"term_taxonomy_id","terms":[36],"operator":"NOT IN"}},"wc_query":"product_query","posts_per_page":12,"ignore_sticky_posts":false,"suppress_filters":false,"cache_results":true,"update_post_term_cache":true,"update_menu_item_cache":false,"lazy_load_term_meta":true,"update_post_meta_cache":true,"post_type":"","nopaging":false,"comments_per_page":"50","no_found_rows":false,"taxonomy":"product_cat","term":"kavalactones"},"tax_query":{"queries":{"relation":"AND","0":{"taxonomy":"product_visibility","terms":[36],"field":"term_taxonomy_id","operator":"NOT IN","include_children":true},"1":{"taxonomy":"product_cat","terms":["kavalactones"],"field":"slug","operator":"IN","include_children":true}},"relation":"AND","queried_terms":{"product_cat":{"terms":["kavalactones"],"field":"slug"}},"primary_table":"wp_posts","primary_id_column":"ID"},"meta_query":{"queries":[],"relation":null,"meta_table":null,"meta_id_column":null,"primary_table":null,"primary_id_column":null},"date_query":false,"queried_object":{"term_id":777,"name":"Kavalactones","slug":"kavalactones","term_group":0,"term_taxonomy_id":777,"taxonomy":"product_cat","description":"Kavalactones are subclass of lactones that are found in kava roots (piper methysticum<\/em><\/a>). Some of the compounds have shown bioactivity, with primary interest in the compounds for their anxiolytic properties. [1] The anxiolytic properties are associated with the possible effects the kavalactones have on GABA-A receptors.\r\n\r\nThere has been notable pushback historically for kava based products for their possible hepatoxic properties. [2]\u00a0 The properties are primarily associated with yangonin and methysticin. The compounds have shown inhibitory activity with CYP enzymes, leading to metabolic dysregulation.\r\n\r\n[1]\u00a0\u201cInfluence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\u201d<\/a>\r\n\r\n[2]\u00a0 \u201cKava: a review of the safety of traditional and recreational beverage consumption\u201d<\/a>","parent":0,"count":6,"filter":"raw"},"queried_object_id":777,"request":"SELECT SQL_CALC_FOUND_ROWS wp_posts.ID\n\t\t\t\t\t FROM wp_posts LEFT JOIN wp_term_relationships ON (wp_posts.ID = wp_term_relationships.object_id)\n\t\t\t\t\t WHERE 1=1 AND ( \n wp_posts.ID NOT IN (\n\t\t\t\tSELECT object_id\n\t\t\t\tFROM wp_term_relationships\n\t\t\t\tWHERE term_taxonomy_id IN (36)\n\t\t\t) \n AND \n wp_term_relationships.term_taxonomy_id IN (777)\n) AND ((wp_posts.post_type = 'product' AND (wp_posts.post_status = 'publish')))\n\t\t\t\t\t GROUP BY wp_posts.ID\n\t\t\t\t\t ORDER BY wp_posts.menu_order ASC, wp_posts.post_title ASC\n\t\t\t\t\t LIMIT 0, 12","posts":[{"ID":8970,"post_author":"5","post_date":"2024-12-11 16:42:40","post_date_gmt":"2024-12-11 21:42:40","post_content":"Desmethoxyyangonin (15345-89-8) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Desmethoxyyangonin may be responsible for the attention promoting effects of kava because of its ability to increase dopamine levels in nucleus accumbens.\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Desmethoxyyangonin - CAS 15345-89-8","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"desmethoxyyangonin","to_ping":"","pinged":"","post_modified":"2024-12-12 10:59:26","post_modified_gmt":"2024-12-12 15:59:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8970","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8965,"post_author":"5","post_date":"2024-12-11 16:20:46","post_date_gmt":"2024-12-11 21:20:46","post_content":"Dihydrokavain (587-63-3) is one of the major kavalactones that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Dihydrokavain is a major contributing factor to the anxiolytic properties of kava products.\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Dihydrokavain - CAS 587-63-3","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dihydrokavain","to_ping":"","pinged":"","post_modified":"2024-12-12 11:04:42","post_modified_gmt":"2024-12-12 16:04:42","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8965","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8976,"post_author":"5","post_date":"2024-12-11 16:54:06","post_date_gmt":"2024-12-11 21:54:06","post_content":"Dihydromethysticin (CAS 19902-91-1) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Dihydromethysticin has been shown to affect the hepatic enzyme CYP1A1\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Dihydromethysticin - CAS 19902-91-1","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"dihydromethysticin","to_ping":"","pinged":"","post_modified":"2025-05-19 13:59:56","post_modified_gmt":"2025-05-19 17:59:56","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8976","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8960,"post_author":"5","post_date":"2024-12-12 10:12:24","post_date_gmt":"2024-12-12 15:12:24","post_content":"Kavain (CAS 500-64-1) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics [1]. The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Kavain also has anticonvulsive properties through attenuation of smooth vascular muscles through ion channel interactions.\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin [2]. The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Kavain - CAS 500-64-1","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"kavain","to_ping":"","pinged":"","post_modified":"2025-05-19 11:07:25","post_modified_gmt":"2025-05-19 15:07:25","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8960","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8973,"post_author":"5","post_date":"2024-12-11 16:48:47","post_date_gmt":"2024-12-11 21:48:47","post_content":"Methysticin (CAS 495-85-2) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). Kavalactones are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1]\r\n\r\nMethysticin exhibits potent neuroprotective effects, supporting cognitive function and reducing oxidative stress in neural tissues. It has demonstrated anxiolytic properties, contributing to kava\u2019s traditional use in stress relief and relaxation. Additionally, Methysticin plays a role in anti-inflammatory pathways, making it relevant for pain management and immune modulation studies.\u00a0The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B.Hepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\n\r\n\r\nOur reference standard is \u226598% pure, ensuring precise analytical results for HPLC, MS, and NMR applications. Ideal for quality control, bioactivity studies, and formulation development.\r\n\r\n\r\n\r\n\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Methysticin - CAS 495-85-2","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"methysticin","to_ping":"","pinged":"","post_modified":"2025-06-10 16:23:06","post_modified_gmt":"2025-06-10 20:23:06","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8973","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},{"ID":8967,"post_author":"5","post_date":"2024-12-11 16:30:16","post_date_gmt":"2024-12-11 21:30:16","post_content":"Yangonin (500-62-9) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Yangonin has shown affinity for binding with cannabinoid receptor CB1.\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Yangonin - CAS 500-62-9","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"yangonin","to_ping":"","pinged":"","post_modified":"2025-05-02 11:19:47","post_modified_gmt":"2025-05-02 15:19:47","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8967","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"}],"post_count":6,"current_post":-1,"before_loop":true,"in_the_loop":false,"post":{"ID":8970,"post_author":"5","post_date":"2024-12-11 16:42:40","post_date_gmt":"2024-12-11 21:42:40","post_content":"Desmethoxyyangonin (15345-89-8) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum<\/i><\/a>). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Desmethoxyyangonin may be responsible for the attention promoting effects of kava because of its ability to increase dopamine levels in nucleus accumbens.\r\n\r\nHepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.\r\n\r\nYou can find the additional kavalactones here<\/a>.\r\n\r\n[1] \"Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site\"<\/a>\r\n\r\n[2] \"Kava: a review of the safety of traditional and recreational beverage consumption\"<\/a>","post_title":"Desmethoxyyangonin - CAS 15345-89-8","post_excerpt":"[wc_measurement_price_calculator_pricing_table]","post_status":"publish","comment_status":"closed","ping_status":"closed","post_password":"","post_name":"desmethoxyyangonin","to_ping":"","pinged":"","post_modified":"2024-12-12 10:59:26","post_modified_gmt":"2024-12-12 15:59:26","post_content_filtered":"","post_parent":0,"guid":"https:\/\/plantaanalytica.com\/?post_type=product&p=8970","menu_order":0,"post_type":"product","post_mime_type":"","comment_count":"0","filter":"raw"},"comment_count":0,"current_comment":-1,"found_posts":6,"max_num_pages":1,"max_num_comment_pages":0,"is_single":false,"is_preview":false,"is_page":false,"is_archive":true,"is_date":false,"is_year":false,"is_month":false,"is_day":false,"is_time":false,"is_author":false,"is_category":false,"is_tag":false,"is_tax":true,"is_search":false,"is_feed":false,"is_comment_feed":false,"is_trackback":false,"is_home":false,"is_privacy_policy":false,"is_404":false,"is_embed":false,"is_paged":false,"is_admin":false,"is_attachment":false,"is_singular":false,"is_robots":false,"is_favicon":false,"is_posts_page":false,"is_post_type_archive":false,"thumbnails_cached":false}

Kavalactones

Classes

Desmethoxyyangonin – CAS 15345-89-8

Dihydrokavain – CAS 587-63-3

Dihydromethysticin – CAS 19902-91-1

Kavain – CAS 500-64-1

Methysticin – CAS 495-85-2

Yangonin – CAS 500-62-9