Dihydrokavain
CAS: 587-63-3
CAT: 8965
Abstract
Dihydrokavain (CAS 587-63-3) is one of the major kavalactones that is naturally occurring in the roots of kava (Piper methysticum). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B. Dihydrokavain is a major contributing factor to the anxiolytic properties of kava products.
Hepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.
You can find the additional kavalactones here.
[1] “Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site”
[2] “Kava: a review of the safety of traditional and recreational beverage consumption”
References
Withanoside IV and its active metabolite
Compound Details
| CAS | 587-63-3 |
|---|---|
| Molecular Weight | 232.3 g/mol |
| Chemical Formula | C₁₄H₁₆O₃ |
| IUPAC | (2S)-4-methoxy-2-(2-phenylethyl)-2,3-dihydropyran-6-one |
| Synonyms | Dihydrokawain |
| SMILES | COC1=CC(=O)O[C@H](C1)CCC2=CC=CC=C2 |
| Purity | 95%+ |
| Storage Temperature | Below −8°C |
| Storage Conditions | Freezer |
$27.00 - $42.50 / milligram
| Range (milligram) | Price ($/milligram) |
|---|---|
| 5 - 9 milligram | $42.50 / milligram |
| 10 - 24 milligram | $39.50 / milligram |
| 25 - 49 milligram | $35.00 / milligram |
| 50 - 99 milligram | $31.00 / milligram |
| 100 - 250 milligram | $27.00 / milligram |
Technical Support
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Products are sold as laboratory reference materials, to be used for diagnostic and in vivo testing. The samples are not certified for veterinary or human use.
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