Emamectin Impurity D

Emamectin Impurity D is a high-purity analytical reference standard of an emamectin B1a related substance, for use in residue analysis, method development, and quality control. Emamectins are a semi-synthetic derivative of avermectins, or more specifically of abamectin. Avermectins are a group of 16-membered macrocyclic lactone derivatives with potent anthelmintic and insecticidal properties. These naturally occurring compounds are generated as fermentation products of the soil actinomycete Streptomyces avermitilis. Abamectins are converted to emamectins through the substitution of the oxygen at the 4″ position with a methylamino group. The resulting structures are labeled as “4″-deoxy-4″-methylamino-avermectin B1”. The modification enhances the potency and stability. The product most often is in the form of a benzoate salt, further improving stability and shelf life.

Emamectin Impurity D is supplied as a white powder with an HPLC purity of 95%+, and should be stored below −18°C in a freezer.

In invertebrates, emamectins affect the nerve and muscle cells by enhancing the effects of glutamate and the glutamate-gated chloride channel. This results in an influx of chloride ions and subsequent paralysis of the invertebrate.

In addition to the major metabolites like Emamectin B1a and Emamectin B1b, Planta Analytica also carries various impurities and fate metabolites. View the related products here.