Intermedine

Abstract

Pyrrolizidine alkaloids are secondary metabolites in plants; about half of these alkaloids exhibit toxicity and carcinogenicity. Pyrrolizidine alkaloids poison grazing animals and domestic livestock through contaminated plants or feed. These alkaloids then poison humans through contaminated food (e.g., grains, honey, and milk), herbal medicine, and supplements. Intermedine and lycopsamine are epimeric monoesters in retronecine-type pyrrolizidine alkaloids. Intermedine (CAS 10285-06-0) and lycopsamine are the predominant pyrrolizidine alkaloids in comfrey (Symphytum officinale). Intermedine and lycopsamine inhibit the ability of hepatocyte cells to proliferate, colonize, and migrate. These alkaloids also induced hepatocyte apoptosis, indicating they are the cause of hepatotoxicity.

See our entire collection of Pyrrolizidine Alkaloids reference standards.

Category: Pyrrolizidine Alkaloids

Compound Details

CAS	10285-06-0
Molecular Weight	299.37
Chemical Structure	C15H25NO5
IUPAC	[(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl(2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate
Synonyms	(+)-Intermedine 3'-epi-lycopsamine
SMILES	CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O
Purity	95%+
Storage Temperature	Below -18 degrees C
Storage Conditions	Dry, freezer

Product Documents

Certificates of Analysis

038-060-101

Safety Data Sheets

MSDS

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250 - 499 milligram	$2.00 / milligram
500 - 1000 milligram	$2.00 / milligram

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