Ruscogenin
CAS: 472-11-7
CAT: 4966
Abstract
Ruscogenin (CAS 472-11-7) is a steroidal saponin that is isolated from Butcher’s Broom (Ruscus aculeatus), so named after the genus. Butcher’s broom is commonly known and has been used by a variety of peoples as a treatment for a variety of ailments. In Europe, it was claimed that the rhizomes could be used as a laxative or diuretic while, in ancient Greece, butcher’s broom was believed to remove kidney stones when added to wine. Ruscogenin has multiple bioactivities and possesses a variety of pharmacological activities including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation and other effects. The mode of action of the ruscogenins in not well understood, but a suggested proposed mechanism hypothesizes that the compound suppresses leokocyte migration through protein and mRNA regulation. Neoruscogenin has been identified as a potent and high-affinity agonist of the nuclear receptor RORα (NR1F1).
You can find additional saponin reference standards here.
References
Withanoside IV and its active metabolite
Compound Details
| CAS | 472-11-7 |
|---|---|
| Molecular Weight | 430.6 g/mol |
| Chemical Formula | C₂₇H₄₂O₄ |
| IUPAC | (1S,2S,4S,5'R,6R,7S,8R,9S,12S,13R,14R,16R)-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.02,9.04,8.013,18]icos-18-ene-6,2'-oxane]-14,16-diol |
| Synonyms | (1β,3β,25R)-Spirost-5-ene-1,3-diol |
| SMILES | CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CC=C6C5(C(CC(C6)O)O)C)C)C)OC1 |
| Purity | 95%+ |
| Storage Temperature | Below −18°C |
| Storage Conditions | Dry, freezer |
PRICE ON REQUEST
Technical Support
Product information is from published literature. Due to the nature of scientific experimentation, results or specific product application may vary (e.g., selectivity, detector response). If you have questions about the product, its application, and associated analytics, please contact our technical support team.
Product Use Disclaimer
Products are sold as laboratory reference materials, to be used for diagnostic and in vivo testing. The samples are not certified for veterinary or human use.
Related Products
