Primulic Acid II
CAS: 65312-86-9
CAT: 11051
Abstract
Primulic Acid II (CAS 208599-88-6) is a triterpenoid saponin from the Primulasaponin family, also known as Primulasaponin II and Primulic Acid 2. It occurs naturally in the roots of Primula species such as Primula veris (cowslip) and Primula elatior (oxlip), typically alongside its companion saponin Primulic Acid I. These plants have played an important role in European traditional herbal medicine for centuries. Practitioners have long used Primula root preparations as expectorants and for respiratory support.
Primulic Acid II has gained scientific interest for its surfactant properties and contribution to the bioactive effects of Primula root extracts. Researchers highlight its role in the expectorant and secretolytic actions of the saponin fraction, which help promote mucus clearance and ease respiratory discomfort. Like other primulasaponins, it exhibits membrane-modulating and mild antibacterial properties that support the overall efficacy of Primula-based preparations.
Beyond its individual activity, Primulic Acid II offers gentle synergistic effects in multi-component herbal formulas. Together with Primulic Acid I, it contributes to the balanced surfactant profile of Primula extracts that supports fluid secretion without excessive hemolytic activity. This gives the saponin fraction a favorable profile compared to more aggressive saponins, making it suitable for wellness applications.
Primulic Acid II serves as a key marker — often quantified together with Primulic Acid I as cumulative saponins — for standardization and quality control. It plays an essential role in ensuring the potency and consistency of Primula root extracts used in nutraceuticals, dietary supplements, herbal teas, tinctures, and phytomedicines. Accurate quantification of both primulic acids helps manufacturers produce reliable batches and meet regulatory compliance standards.
Planta Analytica supplies high-purity Primulic Acid II reference standards. These are ideal for HPLC, UPLC, LC-MS, and other analytical techniques, as well as for pharmacological research and natural product development focused on Primula species. Laboratories worldwide rely on our standards for precise quantification, method validation, and effective standardization of Primula-based products.
References
Withanoside IV and its active metabolite
Compound Details
| CAS | 208599-88-6 |
|---|---|
| Molecular Weight | 1237.3 g/mol |
| Chemical Formula | C₅₉H₉₆O₂₇ |
| IUPAC | (2S,3S,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-5-[(2S,3R,4R,5S,6R)-3,4-dihydroxy-6-(hydroxymethyl)-5-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyoxan-2-yl]oxy-3-hydroxy-6-[[(1S,2R,4S,5R,8R,10S,13R,14R,17S,18R)-2-hydroxy-4,5,9,9,13,20,20-heptamethyl-24-oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosan-10-yl]oxy]oxane-2-carboxylic acid |
| Synonyms | Primulic Acid 2 |
| SMILES | C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H]2O[C@H]3[C@@H]([C@H](O[C@H]([C@@H]3O[C@H]4[C@@H]([C@H]([C@@H]([C@H](O4)CO)O[C@H]5[C@@H]([C@H]([C@@H](CO5)O)O)O)O)O)O[C@H]6CC[C@@]7([C@H]8CC[C@@]91[C@@H]2CC(CC[C@]2(CO9)[C@@H](C[C@]1([C@@]8(CC[C@H]7C6(C)C)C)C)O)(C)C)C)C(=O)O)O)CO)O)O)O)O)O |
| Purity | 95%+ |
| Storage Temperature | Below −18°C |
| Storage Conditions | Dry, freezer |
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Product information is from published literature. Due to the nature of scientific experimentation, results or specific product application may vary (e.g., selectivity, detector response). If you have questions about the product, its application, and associated analytics, please contact our technical support team.
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Products are sold as laboratory reference materials, to be used for diagnostic and in vivo testing. The samples are not certified for veterinary or human use.
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