Desmethoxycurcumin

Desmethoxycurcumin (CAS 22608-11-3) is a naturally occurring curcuminoid isolated from the rhizome of Curcuma longa, the botanical source of turmeric. As a structural analog of curcumin, desmethoxycurcumin lacks one methoxy group. This results in distinct physicochemical properties while retaining the characteristic diarylheptanoid backbone. This compound contributes to the yellow-orange pigmentation of turmeric and plays a critical role in its pharmacological profile.

Desmethoxycurcumin exhibits potent anti-inflammatory and antioxidant activity. This makes it a valuable analytical standard for research in inflammation, oxidative stress, and chronic disease models. It modulates key molecular pathways including NF-κB and COX-2, and has demonstrated efficacy in regulating cellular redox balance and promoting apoptosis in select cancer cell lines. Its role in epigenetic modulation through histone acetyltransferase inhibition further supports its relevance in molecular biology and therapeutic development.

Planta Analytica offers high-purity desmethoxycurcumin as part of its catalog of curcuminoid standards, supporting advanced analytical applications in phytochemistry, pharmacognosy, and natural product research. Companion standards such as curcumin and bisdesmethoxycurcumin are also available to enable comprehensive profiling of turmeric-derived compounds and can be found here.