Cinnamtannin A2

Abstract

Procyanidins are a sub class of proanthocyanidins (PACs), formed from (+) catechin and (-) epicatechin subunits. Procyanidins can be categorized into A-type and B-type, depending on the nature of the interflavan bonds. B-type procyanidins have a single interflavan bond. A-type procyanidins differentiate themselves from B-type procyanidins by containing a second interflavan bond between at least one set of subunits. The most abundant B-type tetramer procyanidin is Cinnamtannin A2 (EEEE) (CAS 86631-38-1), which is found in popular dietary products such as apple skins, cocoa, and grapes.

Cinnamtannin A2 was reported to enhance GLP-1 and insulin secretion in mice, while also upregulating the expression of corticotrophin releasing hormone. Additionally, it exhibits antioxidant, anti-diabetic, and nephroprotective effects.

It is commonly isolated from apples, and cocoa and has HIV-related and antioxidant activities.

You can find additional procyanidin reference standards here.

Categories: Apple PACs, Cocoa PACs, Procyanidins (PACs)

Compound Details

CAS	86631-38-1
Molecular Weight	1155.02
Chemical Formula	C60H50O24
IUPAC	(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R,4S)-2-(3,4-dihydroxyphenyl)-4-[(2R,3R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-8-yl]-8-[(2R,3R,4R)-2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxy-3,4-dihydro-2H-chromen-4-yl]-3,4-dihydro-2H-chromene-3,5,7-triol
Synonyms	Procyanidin Tetramer EEEE
SMILES	C1C(C(OC2=C1C(=CC(=C2C3C(C(OC4=C3C(=CC(=C4C5C(C(OC6=C(C(=CC(=C56)O)O)C7C(C(OC8=CC(=CC(=C78)O)O)C9=CC(=C(C=C9)O)O)O)C1=CC(=C(C=C1)O)O)O)O)O)C1=CC(=C(C=C1)O)O)O)O)O)C1=CC(=C(C=C1)O)O)O
Purity	95%+
Storage Temperature	Below -18 degrees C
Storage Conditions	Dry, freezer

Product Documents

Certificates of Analysis

029-142-A

Safety Data Sheets

MSDS

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$23.00 - $45.00 / milligram

Range (milligram)	Price ($/milligram)
5 - 24 milligram	$45.00 / milligram
25 - 99 milligram	$41.00 / milligram
100 - 249 milligram	$38.00 / milligram
250 - 499 milligram	$36.50 / milligram
500 - 1000 milligram	$23.00 / milligram

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Product information is from published literature. Due to the nature of scientific experimentation, results or specific product application may vary (e.g., selectivity, detector response). If you have questions about the product, its application, and associated analytics, please contact our technical support team.