8,9-Z-Methylamino Avermectin b1a

8,9 Z Methylamino Avermectin B1a, also known as 8,9 Z Emamectin B1a, is used in agrochemical residue analysis, method validation, and environmental fate research. The isomer forms when emamectin B1a undergoes UV driven conversion, making it essential for laboratories that monitor real world residue profiles.

Regulatory residue definitions often include emamectin B1a, B1b, and their 8,9 isomers, which increases the need for accurate quantification. A reliable 8,9 Z MAB1a reference standard supports compliance focused residue chemistry, stability studies, and multi residue method development across agricultural and environmental testing programs.

The compound retains the 16 membered macrocyclic lactone scaffold characteristic of avermectins. It originates from Streptomyces avermitilis fermentation followed by semi synthetic installation of the methylamino group. The 8,9 Z configuration appears as an isomerization product that laboratories track in soil, plant, and complex environmental matrices.

Emamectin related compounds act on glutamate gated chloride channels in invertebrates, increasing chloride influx and disrupting neurotransmission. This mode of action explains the neuromuscular paralysis seen in susceptible pests and supports the importance of monitoring emamectin isomers in environmental risk assessments.

Related emamectin and avermectin standards, impurities, and metabolites are available to support QC and comparability studies. View the related products here.