Primulic Acid I

CAS: 65312-86-9

CAT: 11010

Abstract

Primulic Acid I 65312-86-9 Planta Analytica reference standard

Primulic Acid I (CAS 65312-86-9) is a triterpenoid saponin from the Primulasaponin family, also known as Primulasaponin 1 or Primulic Acid 1. It occurs naturally in the roots of Primula species such as Primula veris (cowslip) and Primula elatior (oxlip). These plants have played an important role in European traditional herbal medicine for centuries. Practitioners have long used Primula root preparations as expectorants and for respiratory support.

Primulic Acid I has gained scientific interest for its surfactant properties and bioactive effects. Researchers highlight its expectorant and secretolytic actions, which help promote mucus clearance and ease respiratory discomfort. It also shows antibacterial activity. For instance, it increases the susceptibility of vancomycin-resistant enterococci (VRE) to antibiotics by disrupting bacterial cell membranes (1). In addition, this saponin contributes to the overall anti-inflammatory and membrane-modulating benefits observed in Primula extracts.

Beyond its respiratory support potential, Primulic Acid I offers gentle synergistic effects in multi-component herbal formulas. It interacts with cell membranes in a balanced way that supports fluid secretion without excessive hemolytic activity. This gives it a favorable profile compared to more aggressive saponins, making it suitable for wellness applications.

Primulic Acid I serves as a key marker for standardization and quality control. It plays an essential role in ensuring the potency and consistency of Primula root extracts used in nutraceuticals, dietary supplements, herbal teas, tinctures, and phytomedicines. Accurate quantification helps manufacturers produce reliable batches and meet regulatory compliance standards.

Planta Analytica supplies high-purity Primulic Acid I reference standards. These are ideal for HPLC, UPLC, LC-MS, and other analytical techniques, as well as for pharmacological research and natural product development. Laboratories worldwide rely on our standards for precise quantification, method validation, and effective standardization of Primula-based products.

References: (1) Saponins increase susceptibility of vancomycin-resistant enterococci to antibiotic compounds. European Journal of Microbiology & Immunology, 2014.

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References

Withanoside IV and its active metabolite

Category: Saponins

Compound Details

CAS	65312-86-9
Molecular Weight	1105.3 g/mol
Chemical Formula	C₅₄H₈₈O₂₃
IUPAC	(2S,3S,4S,5R,6R)-4-[(2S,3R,4S,5R,6R)-4,5-dihydroxy-6-(hydroxymethyl)-3-[(2S,3R,4R,5R,6S) 3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]oxy-3-hydroxy-6-[[(1S,2R,4S,5R,10S,13R,17S) 2-hydroxy-4,5,9,9,13,20,20-heptamethyl-24 oxahexacyclo[15.5.2.01,18.04,17.05,14.08,13]tetracosan-10-yl]oxy]-5-[(2S,3R,4S,5S,6R)-3,4,5 trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxane-2-carboxylic acid
Synonyms	Primulic Acid 1 Primulasaponin I
SMILES	C[C@H]1[C@@H]([C@H]([C@H]([C@@H](O1)O[C@@H]2[C@H]([C@H]([C@H](O[C@H] 2O[C@H]3[C@@H]([C@H](O[C@H]([C@@H]3O[C@H]4[C@@H]([C@H]([C@@H]([C@H] (O4)CO)O)O)O)O[C@H]5CC[C@@]6(C7CC[C@@]89C1CC(CC[C@]1(CO8)[C@@H](C[C @]9([C@@]7(CCC6C5(C)C)C)C)O)(C)C)C)C(=O)O)O)CO)O)O)O)O)O
Purity	95%+
Storage Temperature	Below −18°C
Storage Conditions	Dry, freezer

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