Isoimperatorin – CAS 482-45-1

Isoimperatorin (CAS 482-45-1) is a plant secondary metabolite belonging to the coumarins—specifically, the furanocoumarins. Furocoumarins, are phototoxic and photocarcinogenic. It has been isolated from Angelica archangelica, Angelica dahurica, and Glehnia littoralis, as well as other species from the Apiaceae and Rutaceae families. Angelica a. is cultivated for its sweetly scented edible stems and roots. Traditionally, Imperatorin and Heraclenin have been utilized for a wide variety of ailments.

Isoimperatorin possesses potent antagonistic activity against lipopolysaccharide (LPS)-induced inflammation. The molecule is a furanocoumarin derivative which is structurally related to imperatorin. It is also a tumor necrosis factor (TNF) antagonist and an acetylcholinesterase inhibitor.