Nutraceutical Profiling

Set your nutraceutical product apart with high-quality analytics and rigorous certification. In a market saturated with substandard products, validated methods and premium reference standards can be the key differentiator. Nutraceutical profiling ensures product integrity, giving your business a competitive edge.

Our team of experts is ready to support your product profiling and certification needs. We offer services ranging from routine HPLC analysis using USP monographs to custom-developed analytical methodologies tailored to your specific requirements. Additionally, if suitable reference standards are unavailable or yet to be established, we can produce high-purity, well-characterized standards that meet the stringent expectations of all regulatory bodies.

Service Highlights

Collection of High Quality Reference Standards

Planta Analytica is one of the largest producers of reference standards. Our catalog is filled with unique and exclusive compounds. We have the most complete reference standards sets for a wide range of products. Additionally, being direct to consumer, we offer unbeatable prices.

Analytical Methods Developed by Experts

The experience gained during our purification campaigns helps us create better analytical methods for each product. Further, the in depth understanding of the material properties results in more robust analytical methods. Experience absolute trust in your data.

Fast Turnaround Time on Nutraceutical Profiling

Time is priceless. Therefore, we offer fast turnaround times for all analytical and services, so you aren't waiting on data. Once we receive your sample, its tagged and assigned to one of our analytical experts. Additionally, that person is your point of contact for any questions and after service support.

Examples of Nutraceutical Profiling Methods

Gravimetric Standardization by HPLC

Gravimetric standardization using HPLC analysis is one of the most reliable methods for accurately profiling the active ingredients in nutraceutical products. This approach determines the concentration of active compounds by comparing their detector response—proportional to concentration—against a calibration curve established with reference standards.

While UV detection is the most commonly used method, mass spectrometry provides distinct advantages for compounds with weak chromophores or those present at low concentrations, ensuring precise quantification even in challenging analytical scenarios.

Colorimetric Standardization

Folin–Ciocalteu Assay

The Folin-Ciocalteu (Folin-C) assay is an effective means for determining total phenolic and poly-phenolic content. In effect, it presents phenolic content as a “Gallic Acid equivalent” (GAE) as assay uses gallic acid as the reference.

DMAC ASSAY

4-(Dimethylamino) Cinnamaldehyde (DMAC) Assay is a validated method for determination of total soluble PACs (proanthocyanidins). For example, it’s well suited to profiling products like cranberries and related nutraceuticals. It also offers the benefit of being able to provide information on the relative quantities of A-type vs B-type bonds present in the PACs.

Service Supplement

RAPID STRUCTURAL IDENTIFICATION BY MALDI-TOF/TOF MS

ABSTRACT: Although procyanidins constitute a unique class of polymeric plant secondary metabolites with a variety of biological properties including potent antioxidant activity, structure determination has been challenging, and structures of many complex procyanidins remain uncertain. To expedite the characterization of procyanidins, negative ion matrix-assisted laser desorption ionization high-energy collision-induced dissociation tandem time-of-flight (MALDI-ToF/ToF) mass spectra of 20 isolated procyanidins containing catechin and epicatechin subunits with degrees of polymerization up to five were obtained and evaluated. Structurally significant fragmentation pathways of singly charged, deprotonated molecules were identified representing quinone methide, heterocyclic ring fission, and retro-Diels-Alder fragmentation. The interpretation of the tandem mass spectra for sequencing A-type, B-type, mixed-type, linear, and branched procyanidins is explained using specific examples of each.

Nutraceutical Reference Standards

Explore our most sought-after nutraceutical reference standards. Planta Analytica offers an extensive in-stock library of high-quality standards, covering a diverse range of natural products to support your profiling needs.

We are the leading supplier of procyanidin reference standards, with a comprehensive collection that includes references for cocoa, cinnamon, cranberry, peanut skins, apple skins, and many more.

If your required target compounds are not available in our catalog, contact us to inquire about our custom isolation services—we are equipped to develop high-purity standards tailored to your specific requirements