Riddelliine N-oxide – CAS 75056-11-0

Riddelliine N-oxide (CAS 75056-11-0) is an oxidized form of the pyrrolizidine alkaloid (PA) isolated from Senecio riddellii and also found in Jacobea vulgaris and senecio vulgaris, among other plants in the Senecio genus. Riddelliine N-oxide can be present in honey made from the nectar of the plant and has become a compound of interest for monitoring Pyrrolizidine alkaloid (PA) content in honey and related products.

PAs are secondary metabolites in plants; about half of these alkaloids exhibit toxicity and carcinogenicity. Pyrrolizidine alkaloids poison grazing animals and domestic livestock through contaminated plants or feed. These alkaloids then poison humans through contaminated food (e.g., grains, honey, and milk), herbal medicine, and supplements. The plant is also toxic to livestock, and considered and undesirable wildflower.

Find the entire collection of pyrrolizidine alkaloids here.