- Required Weight missing.
Methysticin – 495-85-2
Abstract
Methysticin (495-85-2) is the major kavalactone that is naturally occurring in the roots of kava (Piper methysticum). The compounds are studied for their bioactive properties, with a primary focus on the effects as anxiolytics. [1] The activity associated with the major kavalactones, excluding desmethoxyyangonin, includes potentiation of the GABAA receptor potentiators, reuptake inhabitation of norepinephrine and dopamine, CB1 receptor binding, inhibition of voltage-gated sodium and calcium channels, and reversible inhibition of monoamine oxidase B.
Hepatoxic properties have been observed in several of the kavalactones, primarily methysticin and yangonin. [2] The compounds affect a group of enzymes called CYP450 that are involved in metabolism.
You can find the additional kavalactones here.
[1] “Influence of Genuine Kavapyrone Enantiomers on the GABAA Binding Site”
[2] “Kava: a review of the safety of traditional and recreational beverage consumption”
Compound Details
| CAS # | 495-85-2 |
|---|---|
| Molecular Weight | 274.27 |
| Chemical Formula | C15H14O5 |
| IUPAC | (2R)-2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one |
| Synonyms | Kavatin |
| SMILES | COC1=CC(=O)O[C@H](C1)/C=C/C2=CC3=C(C=C2)OCO3 |
| Purity | 95%+ |
| Storage Temperature | <-8C |
| Storage Conditions | Freezer |
Product Use Disclaimer
Products are sold as laboratory reference materials, to be used for diagnostic and in vivo testing. The samples are not certified for veterinary or human use.
$27.00 - $42.00 / milligram
| Range (milligram) | Price ($/milligram) |
|---|---|
| 5 - 9 milligram | $42.00 / milligram |
| 10 - 24 milligram | $37.00 / milligram |
| 25 - 49 milligram | $33.50 / milligram |
| 50 - 99 milligram | $30.00 / milligram |
| 100 - 250 milligram | $27.00 / milligram |
Technical Support
Product information is from published literature. Due to the nature of scientific experimentation, results or specific product application may vary (e.g., selectivity, detector response). If you have questions about the product, its application, and associated analytics, please contact our technical support team.
Related products
-
View Item
Desmethoxyyangonin – CAS 15345-89-8
$32.50 - $58.00 / milligram -
View Item
Kavain – 500-64-1
$1.65 - $12.00 / milligram -
View Item
Dihydromethysticin – 19902-91-1
$27.50 - $40.00 / milligram -
View Item
Dihydrokavain – CAS 587-63-3
$27.00 - $42.50 / milligram -
View Item
Yangonin – 500-62-9
$28.00 - $46.00 / milligram
