Abstract
Pyrrolizidine alkaloids are secondary metabolites in plants; about half of these alkaloids exhibit toxicity and carcinogenicity. Pyrrolizidine alkaloids poison grazing animals and domestic livestock through contaminated plants or feed. These alkaloids then poison humans through contaminated food (e.g., grains, honey, and milk), herbal medicine, and supplements. Intermedine and lycopsamine are epimeric monoesters in retronecine-type pyrrolizidine alkaloids. Intermedine (CAS 10285-06-0) and lycopsamine are the predominant pyrrolizidine alkaloids in comfrey (Symphytum officinale). Intermedine and lycopsamine inhibit the ability of hepatocyte cells to proliferate, colonize, and migrate. These alkaloids also induced hepatocyte apoptosis, indicating they are the cause of hepatotoxicity.
See our entire collection of Pyrrolizidine Alkaloids reference standards.
Compound Details
CAS | 10285-06-0 |
---|---|
Molecular Weight | 299.37 |
Chemical Structure | C15H25NO5 |
IUPAC | [(7R,8R)-7-hydroxy-5,6,7,8-tetrahydro-3H-pyrrolizin-1-yl]methyl(2S)-2-hydroxy-2-[(1R)-1-hydroxyethyl]-3-methylbutanoate |
Synonyms | (+)-Intermedine |
SMILES | CC(C)C(C(C)O)(C(=O)OCC1=CCN2C1C(CC2)O)O |
Purity | 95%+ |
Storage Temperature | Below -18 degrees C |
Storage Conditions | Dry, freezer |
Product Documents
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Products are sold as laboratory reference materials, to be used for diagnostic and in vivo testing. The samples are not certified for veterinary or human use.
$2.00 / milligram
Range (milligram) | Price ($/milligram) |
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5 - 24 milligram | $2.00 / milligram |
25 - 99 milligram | $2.00 / milligram |
100 - 249 milligram | $2.00 / milligram |
250 - 499 milligram | $2.00 / milligram |
500 - 1000 milligram | $2.00 / milligram |
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Product information is from published literature. Due to the nature of scientific experimentation, results or specific product application may vary (e.g., selectivity, detector response). If you have questions about the product, its application, and associated analytics, please contact our technical support team.
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