Ruscogenin – CAS 472-11-7

Ruscogenin (CAS 472-11-7) is a steroidal saponin that is isolated from Butcher’s Broom (Ruscus aculeatus), so named after the genus. Butcher’s broom is commonly known and has been used by a variety of peoples as a treatment for a variety of ailments. In Europe, it was claimed that the rhizomes could be used as a laxative or diuretic while, in ancient Greece, butcher’s broom was believed to remove kidney stones when added to wine. Ruscogenin has multiple bioactivities and possesses a variety of pharmacological activities including anti-inflammatory properties, platelet aggregation inhibition, pulmonary hypertension lowering properties, acute lung injury alleviation and other effects. The mode of action of the ruscogenins in not well understood, but a suggested proposed mechanism hypothesizes that the compound suppresses leokocyte migration through protein and mRNA regulation. Neoruscogenin has been identified as a potent and high-affinity agonist of the nuclear receptor RORα (NR1F1).

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