TECHNOLOGY
CHROMATOGRAPHIC RESINS
Planta Analytica has a large selection of chromatographic resins from leading manufacturers, including Purolite, Mitsubishi, DuPont Water Solutions, and LANXESS. Additionally, our library of resins includes adsorbent, ion-exchange (anion / cation), and gel filtration/size exclusion products.
We are constantly exploring the potential of resins in novel applications to create more economical processes. Consequently, we have introduced the use of this technology to new markets, improving their competitiveness by reducing costs.
In addition to the economic benefits, resins offer a more environmentally friendly approach to chromatography. Through their higher loading capacity, application of greener solvents, and reusability, resin-based processes consume less energy and produce less waste.
Benefits of CHromatographic Resins
Resins have provided the industry with a more economically and environmentally responsible means of compound isolation. Their chemical and mechanical stability ensures that they have great usability. Also, this stability allows users to clean the resin in place for simple, cost-effective operations.
Longevity & Reusability
When developing methods for industry, solid phases constitute a major part of process consumable cost. Therefore, they can be the determining factor whether a process is economically feasible. Organic chromatographic resins significantly lower processing costs because of their superior chemical and mechanical stability. These resins require replacement far less frequently than silica-based solid phases, without sacrificing loading capacities. Additionally, chromatographic resins are robust. They can withstand many regeneration cycles without a loss in performance.
Selectivity
Chromatographic resins offer unique selectivity that can enable purification of even the most challenging compounds. The highly selective nature of certain resins can decrease method development time. Furthermore, the resulting process is more efficient with fewer purification steps. Additionally, resins with targeted selectivity can significantly improve the overall efficiency by lowering background binding.
Designed for Industry
Chromatographic resins are well-suited for commercial applications thanks to their low consumable costs and high throughput. The large surface area of the resins allows for high binding capacity, while the large particle sizes reduce system back pressure, allowing high flowrates. The lower pressure operation also decreases capital costs through the use of less expensive hardware. The resin’s high mechanical durability ensures consistency in operations, minimizing downtime.
Frequently Asked Questions
Our library of resins includes adsorbent, ion-exchange (anion / cation), and gel filtration/size exclusion chromatography resins.
Experience! However, we also take into account the resin’s characteristics, including particle size, pore size, surface area, and chemistry. All of these properties influence the capacity, resolution, and separation kinetics of chromatographic resins.
We have found that resins offer unique properties when compared to silica, have high loading capacities, and are reusable. Our clients appreciate the low costs associated with utilizing resins, the linear scaling, and the ease of regeneration.
Ion exchange resins allow for the separation of ions based on their affinity for counterions. In cation exchange resins, the resin is negatively charged with positively charged counterions (cations). In anion exchange resins, the resin is positively charged with negatively charged counterions (anions).
These types of resins offer high-resolution separation of compounds according to their molecular weight. Size exclusion resins contain pores of varying sizes. Large molecules are eluted with the void volume, while small molecules are delayed by the pores. Gel filtration (GF) resins are extremely gentle, as there is no chemical interaction between the compounds and the resin beads.
In order to extend the resin’s lifetime, sufficient cleaning and proper storage are crucial! Sodium hydroxide is the most common (and inexpensive!) cleaning agent. For most resins, storage in aqueous alcoholic conditions is recommended.
It depends! The most common chromatographic resins are polymeric structures, based on a styrene-divinyl benzene (PS-DVB) matrix or an acrylic matrix.