To be able to sell, use, or biologically test your product the regulations set forth by various
agencies such as the FDA, USDA must be met. The regulatory approval process requires the
and characterization of structures for all impurities exceeding 0.1% concentration in the
To ensure accurate structural elucidation we work with cutting-edge laboratories to acquire high
resolution NMR data, accurate mass spectroscopy and UV-VIS spectrum.
Impurity Isolation vs. Small Molecule Isolation
Although impurity isolation generally falls into small molecule isolation, it has its own
distinctive character. Before the impurities can be purified by preparative chromatography their
relative concentration must be brought up at least into a minimum range of 10 – 30% by the
enrichment techniques, which comprise chromatographic as well as non-chromatographic methods.
usually constitutes the most difficult and time consuming stage requiring experience and skill.
final step is often done by preparative HPLC and often looks like a formality.
Moreso, when dealing with bacterially derived products such as agrochemicals, the product
a single major component and several impurities that are structurally very similar. The
similarity as well as the large disparity in concentration between main component and impurities
requires non-conventional approaches.
Specialization in Wide Range of Agrochemicals
We have developed an extensive expertise in impurity isolation for some of those most
agrochemical products including abamectins, emamectins, pyrethrins, azadirachtins and others.