Efficient, Baseline Separation of Pyrethrins by Centrifugal Partition Chromatography

AbstractPyrethrins are natural pesticides present in the oil extracted from the flowers of Chrysanthemum cinerariaefolium. They are potent ion-channel neurotoxins which have higher selective toxicity for insects compared to mammals. These phytochemicals have an exceptionally safe environmental profile and are an attractive natural alternative to organophosphate insecticides currently used in agric... READ MORE

Trimeric and Tetrameric A‑Type Procyanidins from Peanut Skins

AbstractPeanut skins are a rich source of oligomeric and polymeric procyanidins. The oligomeric fractions are dominated by dimers, trimers, and tetramers. A multistep chromatographic fractionation led to the isolation of four new A-type procyanidins of tri- and tetrameric structures. The structures of the new trimers were defined by NMR, electronic circular dichroism, and MS data as epicatechin-(... READ MORE

Influence of Degree-of-Polymerization and Linkage on the Quantification of Proanthocyanidins using 4‑Dimethylaminocinnamaldehyde (DMAC) Assay

AbstractProanthocyanidins (PACs) are naturally occurring flavonoids possessing health beneficial bioactivities. Their quantification often utilizes the 4-dimethylaminocinnamaldehyde (DMAC) spectrophotometric assay with the assumption that molar absorption coefficients (MACs) are similar across the various PAC species. To assess the validity of this assumption, individual PAC monomers and oligom... READ MORE

Reactivation of latent HIV-1 by new semi-synthetic ingenol esters

AbstractThe ability of HIV to establish long-lived latent infection is mainly due to transcriptional silencing of viral genome in resting memory T lymphocytes. Here, we show that new semi-synthetic ingenol esters reactivate latent HIV reservoirs. Amongst the tested compounds, 3-caproyl-ingenol (ING B) was more potent in reactivating latent HIV than known activators such as SAHA, ingenol 3,20-diben... READ MORE

Characterization of Primary Standards for Use in the HPLC Analysis of the Procyanidin Content of Cocoa and Chocolate Containing Products [FREE DOWNLOAD]

AbstractThis report describes the characterization of a series of commercially available procyanidin standards ranging from dimers DP = 2 to decamers DP = 10 for the determination of procyanidins from cocoa and chocolate. Using a combination of HPLC with fluorescence detection and MALDI-TOF mass spectrometry, the purity of each standard was determined and these data were used to determine relative... READ MORE

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